Xtandi 40mg, containing the active ingredient Enzalutamide, is an advanced oral medication used primarily for the treatment of prostate cancer. Manufactured by Astellas Pharma, this medicine is often prescribed to patients with metastatic castration-resistant prostate cancer (mCRPC) and non-metastatic castration-resistant prostate cancer (nmCRPC). It comes in a convenient pack of 112 capsules, designed for daily use under medical supervision.
Uses of Xtandi 40mg
Xtandi is used to treat men whose prostate cancer:
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Has spread to other parts of the body (metastatic)
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Has stopped responding to surgical or chemical treatments that lower testosterone
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Has not spread but is growing despite hormone therapy (non-metastatic)
It may be prescribed alone or in combination with other treatments such as androgen deprivation therapy (ADT).
How Xtandi Works
Xtandi works by targeting and blocking the action of androgens (male hormones like testosterone), which fuel the growth of prostate cancer cells. Specifically, it inhibits the androgen receptor within cancer cells, preventing these hormones from attaching and activating the cancer-promoting signals. Unlike earlier hormonal therapies, Xtandi blocks androgen signaling at multiple steps, making it more effective for advanced stages of prostate cancer.
Dosage and Administration
The usual recommended dose is 160 mg once daily, which equals four 40mg capsules, taken at the same time each day. Xtandi can be taken with or without food, but it must be swallowed whole—do not chew or crush the capsules.
Side Effects
Like all medications, Xtandi may cause side effects, including:
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Fatigue
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High blood pressure
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Back pain
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Hot flashes
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Seizures (rare but serious)
Patients should report any unusual symptoms to their healthcare provider promptly.
Precautions
Xtandi is not for use in women or children. Men taking Xtandi should use effective contraception during treatment and for three months after the final dose due to potential harm to unborn babies.
Always consult your doctor before starting or stopping any cancer medication.
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