Uses of Ibrance 125mg Tablets

Ibrance 125mg (palbociclib) is a targeted medication specifically designed to treat advanced breast cancer in adults. It is particularly effective for:

• HR-positive (hormone receptor-positive) breast cancer: This type of cancer grows in response to hormones like estrogen or progesterone.
• HER2-negative breast cancer: This indicates that the cancer cells do not have excessive levels of the HER2 protein.

How Does Ibrance 125mg Tablet Work?

Ibrance (palbociclib) functions as a targeted therapy, focusing on cancer cells while sparing healthy cells. It works by:

• Blocking CDK4 and CDK6 enzymes: These proteins play a crucial role in cell growth and division. By inhibiting them, Ibrance slows the growth and spread of cancer cells.

In essence, Ibrance acts as a brake on cancer cell proliferation, allowing the body a better opportunity to combat the disease.

How Should You Take Ibrance?

Ibrance 125mg tablets follow a specific dosing cycle:

• 3 weeks on: Take one tablet daily for 21 days.
• 1 week off: Do not take Ibrance for the following 7 days.

Administration Guidelines:

• Swallow the tablet whole: Do not chew, crush, or split it.
• Timing: You can take it with or without food, but aim to take it at the same time each day for consistency.
• Avoid grapefruit: Grapefruit can interact with Ibrance, so it’s best to steer clear of it.

Ibrance 125mg tablets contain palbociclib, a member of the CDK4/6 inhibitor class, which blocks proteins that promote cancer cell growth. It is typically used alongside hormone therapy, such as letrozole or fulvestrant, for postmenopausal women or men with HR-positive, HER2-negative breast cancer.

Key Uses:

• Treats HR+/HER2− advanced or metastatic breast cancer.
• Used in combination with hormone therapy.
• Slows cancer progression.
• Improves progression-free survival.

How It Works:

Ibrance specifically targets and inhibits cyclin-dependent kinases 4 and 6 (CDK4/6), which are essential for cell division. By blocking these enzymes, Ibrance helps prevent cancer cells from multiplying, thereby slowing tumor growth and aiding in disease control.

Dosage & Administration:

• Typical dose: One 125mg tablet taken once daily for 21 consecutive days, followed by a 7-day break (28-day cycle).
• Take with food: Preferably at the same time each day.
• Dose adjustments: May be necessary based on side effects or lab results.
• Prescription required: Treatment must be initiated and monitored by an oncologist.

Side Effects:

Common side effects may include:

• Low white blood cell count (neutropenia)
• Fatigue
• Nausea
• Hair thinning or loss
• Mouth sores
• Diarrhea

Serious side effects can include infections due to low immunity, liver function changes, or blood clots. Regular blood tests are essential during treatment.

Precautions:

• Not suitable for use during pregnancy or breastfeeding.
• Effective birth control is recommended during treatment and for at least 3 weeks after the last dose.
• Avoid grapefruit juice, which may elevate drug levels in the blood.
• Inform your doctor about all other medications you are taking.

Availability in Pakistan:

Ibrance 125mg tablets are available at leading pharmacies and online medical platforms in Pakistan. As a prescription-only oncology medication, treatment should be initiated and supervised by a qualified cancer specialist.