Prograf 1mg
Prograf 1mg Capsule (Tacrolimus) is an immunosuppressant medication used to prevent organ rejection in patients who have undergone kidney, liver, or heart transplants. Tacrolimus works by suppressing the body’s immune response, thereby reducing the risk of the immune system attacking the transplanted organ.
Each capsule contains 1mg of Tacrolimus, offering precise dosing to help maintain therapeutic drug levels. Prograf is an essential part of post-transplant therapy and is usually prescribed in combination with other immunosuppressive agents such as corticosteroids or mycophenolate mofetil.
Prograf is administered orally, typically twice daily, and dosing is individualized based on blood trough levels, body weight, and the type of transplant. Regular monitoring of Tacrolimus levels in the blood is critical to avoid under-immunosuppression (risk of rejection) or toxicity.
Common side effects include tremors, headache, nausea, high blood pressure, kidney function changes, and increased susceptibility to infections. Long-term use requires monitoring for nephrotoxicity, neurotoxicity, and blood glucose levels due to the risk of developing diabetes post-transplant.
Store Prograf capsules at room temperature (below 30°C), in a dry place, protected from light and moisture.
Prograf 1mg Capsule (Tacrolimus)
Prograf 1mg Capsule (Tacrolimus) is a calcineurin inhibitor used to prevent organ rejection in patients who have received kidney, liver, or heart transplants. It works by inhibiting T-lymphocyte activation, which reduces the immune response and lowers the risk of graft rejection.
Indications
- Prevention of organ transplant rejection (kidney, liver, heart)
- Treatment of rejection episodes in patients unresponsive to other immunosuppressants
Prograf plays a key role in post-transplant immunosuppressive therapy. It is commonly combined with corticosteroids and antiproliferative agents such as azathioprine or mycophenolate mofetil. The drug is taken orally twice a day, preferably on an empty stomach for consistent absorption. Dosage adjustments depend on the patient’s blood Tacrolimus levels, kidney function, and overall immunosuppressive needs.
Moreover, therapeutic drug monitoring is essential. If levels are too low, the risk of rejection rises. However, excessive levels can cause nephrotoxicity, neurotoxicity, and metabolic issues like hyperglycemia.
Common Side Effects
- Tremors, headache, and insomnia
- Nausea or diarrhea
- High blood pressure
- Elevated creatinine levels (nephrotoxicity)
- Increased blood sugar (risk of post-transplant diabetes)
Patients must avoid grapefruit juice, as it can interfere with how Tacrolimus is metabolized. Routine tests are necessary to monitor kidney function, blood glucose, and drug levels.
Storage Instructions
Keep Prograf capsules at room temperature (below 30°C) in a dry place, away from direct sunlight.
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